Nanopore Reader 100 KHz

Innovative and compact ultra-low noise amplifier for single-channel recordings. Suitable for biological nanopores, solid-state nanopores and nanoparticle detection.

One instrument, two different applications

Biological Pores in Bilayer Lipid Membranes

Biological pores are transmembrane proteins that can be reconstituted into a planar lipid bilayer. Measuring changes in the ion currents flowing through biological nanopores allows to quickly determine general properties of analytes crossing lipid bilayers.

Solid State Pores

Solid-state nanopores are artificially formed in non-conductive silicon nitride membranes. Their applications span from DNA translocation to analyte characterization by measuring ion currents. The resistive-pulse sensing technique allows for the analysis of  individual nanoparticles, liposomes, exosomes, and viruses. 

Biological Pores in Bilayer Lipid Membranes

The BLM Chip, or Bilayer Lipid Membrane Chip, is a microfluidic system serving as the interface between the pore and the current amplifier. Depending on your needs, you can choose between two types of BLM Chips, featuring either horizontal or vertical bilayer membrane formation. Both feature two easily accessible cis and trans chambers, separated by a membrane housing the aperture for creating your lipid membrane.

BLM Chip Standard

Made of a 12.5 µm thick layer of Polyimide embedded in a PMMA frame housing two compartments. The aperture is laser-drilled into the polyimide sheet for the formation of a horizontal lipid bilayer. Both cis/trans compartments are easily accessible from the top side. Electrodes are integrated in the chip. 


Designed to facilitate the creation of vertical lipid bilayer membranes using either the Montal Müller technique or the pseudo bubble method. It consists of two adjacent PMMA-made parts that form two chambers, separated by a 25 μm thick polyimide sheet housing the micro-aperture for lipid membrane formation.

Lipid Bilayer Formation: Horizontal

Chambers Volume: 60 µl

Aperture Sizes: 100 ; 150  µm

Typical Membrane Capacitance (DPhPC-made lipid membranes): 20-50 pF in 100 µm, and 50-110 pF in 150 µm.                                                                                                

Non Replaceable Printed Silver Electrodes

Lipid Bilayer Formation: Vertical

Chambers Volume: 100 µl

Aperture Sizes: 50 ; 75 ; 100 ; 140 µm

Typical Membrane Capacitance (DPhPC-made lipid membranes; 25 µm hole thickness): 20-40 pF in 50 µm, 40-60 pF in 75 µm, and 60-90 pF in 100 µm, 90-140 pF in 140 µm

Replaceable External Silver Wires

Reusable Chips: depending on your application you can use multiple times a single BLM Chip

Use Cases

Your Lipid Bilayer Experiment using the BLM Chip

Solid State pores

The Nanopore Flowcell is a microfluidic system serving as the interface between the nanopore chip and the current reader. Depending on your needs, you can choose between different materials. The nanopore chip can be rapidly changed without tools and the flowcell is reusable.


Nanopore Chip: Vertical

Chambers Volume: 10 µl min – 60 µl max

Flowcell Materials: PMMA or Teflon

Replaceable External Silver Wires

Nanopore Chip not Included, buy it from Norcada

Nanopore Chip compatibility: 200 µm thick and 4×4 or 5×5 mm² square chips

Reusable Flowcell: depending on your application you can use multiple times a single Flowcell

Use Cases

Why to choose the eNPR?

Miniaturized – Handheld instruments vs. bulky setups

Ready to use – Tools free, just insert the flowcell in the device

High quality performances – low noise measurements

Affordable – We enable technologies for everyone!

Nanopore Reader 100 kHz Noise Levels

  • Open input (RMS) noise (Voltage range ±700mV) : 0.06 pA rms @ 625Hz; 0.3 pA rms @ 10 kHz; 2.4 pA rms @ 100 kHz
  • Open input (RMS) noise (Voltage range ±2000mV) : 0.08 pA rms @ 1kHz; 0.42 pA rms @ 10 kHz; 3.7 pA rms @ 100 kHz
  • Current ranges: ±200pA (Gain 2.25GΩ), ±2nA (Gain 225MΩ), ±20nA (Gain 22.5MΩ), ±200nA (Gain 2.25MΩ)
  • Voltage hold ranges: ±700mV (ultra low noise); ±2000mV (low noise)
  • Parametric voltage protocols
  • Max sampling rate: 200 ksps
  • Selectable x4 oversampling (max final sampling rate 800 ksps)
  • Available bandwidth between 62.5 Hz to 100 kHz
  • Auto electrodes voltage offset fine compensation
  • Continuous Capacitance and Resistance estimation
  • USB powered
  • Size & Weight: 101 x 44 x 18 mm, 140 g


Custom device development

With our custom ASIC design technology we can help you configure specific tools and solutions for your applications.

Let us know how we can help you design the tools and software you need.