Papers & Reviews

Saponaro, A., et al., Validation of the binding stoichiometry between HCN channels and their neuronal regulator TRIP8b by single molecule measurements. Frontiers in Physiology, 2022.

Merseburg, A., et al., Seizures, behavioral deficits, and adverse drug responses in two new genetic mouse models of HCN1 epileptic encephalopathy. eLife, 2022.

Mnatsakanyan, N et al., Mitochondrial ATP synthase c-subunit leak channel triggers cell death upon loss of its F1 subcomplex. Cell Death Differ (2022)

Gutierrez BC et al., Honeybee Brain Oscillations Are Generated by Microtubules. The Concept of a Brain Central Oscillator. Front Mol Neurosci. 2021 Sep 29;14:727025.

Porro A et al., Do the functional properties of HCN1 mutants correlate with the clinical features in epileptic patients? Prog Biophys Mol Biol. 2021 Nov;166:147-155.

Saponaro A et al., Gating movements and ion permeation in HCN4 pacemaker channels. Mol Cell. 2021 Jul 15;81(14):2929-2943.e6.

Porro A et al., Rational design of a mutation to investigate the role of the brain protein TRIP8b in limiting the cAMP response of HCN channels in neurons. J Gen Physiol. 2020 Sep 7;152(9):e202012596.

Porro A et al., The HCN domain couples voltage gating and cAMP response in hyperpolarization-activated cyclic nucleotide-gated channels. Elife. 2019 Nov 26;8:e49672. doi: 10.7554/eLife.49672. PMID: 31769408; PMCID: PMC6894927.

Del Rocío Cantero M et al., Actin filaments modulate electrical activity of brain microtubule protein two-dimensional sheets. Cytoskeleton (Hoboken). 2020 Mar;77(3-4):167-177.

Porro et al., Investigating the effects of lamotrigine on HCN channels: a test case for a new miniaturized patch-clamp amplifier. Poster presentation at BPS meeting.

Porro et al., Helices D and E of HCN4 channel tune the cAMP responsiveness. Poster presentation at BPS meeting.

 

Niatsetskaya Z et al., Cyclophilin D-dependent oligodendrocyte mitochondrial ion leak contributes to neonatal white matter injury. J Clin Invest. 2020 Oct 1;130(10):5536-5550.

Amodeo GF et al., Formation of High-Conductive C Subunit Channels upon Interaction with Cyclophilin D. Int J Mol Sci. 2021 Oct 13;22(20):11022.

Amodeo GF et al., C subunit of the ATP synthase is an amyloidogenic calcium dependent channel-forming peptide with possible implications in mitochondrial permeability transition. Sci Rep. 2021 Apr 22;11(1):8744.

Neginskaya MA et al., ATP Synthase C-Subunit-Deficient Mitochondria Have a Small Cyclosporine A-Sensitive Channel, but Lack the Permeability Transition Pore. Cell Rep. 2019 Jan 2;26(1):11-17.e2.

Piguet F et al., Identification of single amino acid differences in uniformly charged homopolymeric peptides with aerolysin nanopore. Nat Commun. 2018 Mar 6;9(1):966.

Ludtmann MHR et al., α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease. Nat Commun. 2018 Jun 12;9(1):2293.

Meng FN et al., Structural stability of the photo-responsive DNA duplexes containing one azobenzene via a confined pore. Chem Commun (Camb). 2017 Aug 22;53(68):9462-9465. doi: 10.1039/c7cc04599a. PMID: 28795695.

Asandei A et al., Electroosmotic Trap Against the Electrophoretic Force Near a Protein Nanopore Reveals Peptide Dynamics During Capture and Translocation. ACS Appl Mater Interfaces. 2016 May 25;8(20):13166-79.

Mamad-Hemouch H et al., Biomimetic Nanotubes Based on Cyclodextrins for Ion-Channel Applications. Nano Lett. 2015 Nov 11;15(11):7748-54.

Patch Clamp

Saponaro, A., et al., Validation of the binding stoichiometry between HCN channels and their neuronal regulator TRIP8b by single molecule measurements. Frontiers in Physiology, 2022.

Merseburg, A., et al., Seizures, behavioral deficits, and adverse drug responses in two new genetic mouse models of HCN1 epileptic encephalopathy. eLife, 2022.

Mnatsakanyan, N et al., Mitochondrial ATP synthase c-subunit leak channel triggers cell death upon loss of its F1 subcomplex. Cell Death Differ (2022)

Gutierrez BC et al., Honeybee Brain Oscillations Are Generated by Microtubules. The Concept of a Brain Central Oscillator. Front Mol Neurosci. 2021 Sep 29;14:727025.

Porro A et al., Do the functional properties of HCN1 mutants correlate with the clinical features in epileptic patients? Prog Biophys Mol Biol. 2021 Nov;166:147-155.

Saponaro A et al., Gating movements and ion permeation in HCN4 pacemaker channels. Mol Cell. 2021 Jul 15;81(14):2929-2943.e6.

Porro A et al., Rational design of a mutation to investigate the role of the brain protein TRIP8b in limiting the cAMP response of HCN channels in neurons. J Gen Physiol. 2020 Sep 7;152(9):e202012596.

Porro A et al., The HCN domain couples voltage gating and cAMP response in hyperpolarization-activated cyclic nucleotide-gated channels. Elife. 2019 Nov 26;8:e49672. doi: 10.7554/eLife.49672. PMID: 31769408; PMCID: PMC6894927.

Del Rocío Cantero M et al., Actin filaments modulate electrical activity of brain microtubule protein two-dimensional sheets. Cytoskeleton (Hoboken). 2020 Mar;77(3-4):167-177.

Porro et al., Investigating the effects of lamotrigine on HCN channels: a test case for a new miniaturized patch-clamp amplifier. Poster presentation at BPS meeting.

Porro et al., Helices D and E of HCN4 channel tune the cAMP responsiveness. Poster presentation at BPS meeting.

 

eONE

Niatsetskaya Z et al., Cyclophilin D-dependent oligodendrocyte mitochondrial ion leak contributes to neonatal white matter injury. J Clin Invest. 2020 Oct 1;130(10):5536-5550.

Amodeo GF et al., Formation of High-Conductive C Subunit Channels upon Interaction with Cyclophilin D. Int J Mol Sci. 2021 Oct 13;22(20):11022.

Amodeo GF et al., C subunit of the ATP synthase is an amyloidogenic calcium dependent channel-forming peptide with possible implications in mitochondrial permeability transition. Sci Rep. 2021 Apr 22;11(1):8744.

Neginskaya MA et al., ATP Synthase C-Subunit-Deficient Mitochondria Have a Small Cyclosporine A-Sensitive Channel, but Lack the Permeability Transition Pore. Cell Rep. 2019 Jan 2;26(1):11-17.e2.

Piguet F et al., Identification of single amino acid differences in uniformly charged homopolymeric peptides with aerolysin nanopore. Nat Commun. 2018 Mar 6;9(1):966.

Ludtmann MHR et al., α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease. Nat Commun. 2018 Jun 12;9(1):2293.

Meng FN et al., Structural stability of the photo-responsive DNA duplexes containing one azobenzene via a confined pore. Chem Commun (Camb). 2017 Aug 22;53(68):9462-9465. doi: 10.1039/c7cc04599a. PMID: 28795695.

Asandei A et al., Electroosmotic Trap Against the Electrophoretic Force Near a Protein Nanopore Reveals Peptide Dynamics During Capture and Translocation. ACS Appl Mater Interfaces. 2016 May 25;8(20):13166-79.

Mamad-Hemouch H et al., Biomimetic Nanotubes Based on Cyclodextrins for Ion-Channel Applications. Nano Lett. 2015 Nov 11;15(11):7748-54.

Nanopore Reader