The new tiny amplifier designed for high quality patch clamp recordings in both voltage clamp and current clamp modes
ePatch
The low-noise amplifier, the pulse generator and the digitizer are included within the small headstage (only 42 x 18 x 78 mm) that can be directly installed to the micromanipulator mounting plate and powered by the USB port of a laptop without the need of any external bulky digitizer and control unit.

Applications






EZ Patch - the new ePatch software interface
EZ Patch software is the new patch-clamp electrophysiology software developed and released by Elements for easy control of the ePatch amplifier. EZ Patch allows:
- Customizable user-friendly Windows-format interface
- Real-time display of voltage and current digitized data
- Parametric voltage protocols editor
- Automatic or manual control of compensation settings
- Membrane parameters estimation to keep track of cell health
- Real-time data analysis (C-fast – estimation, noise, I/V graph, current histogram, etc.)
- Digital LabBook
- Data output saving formats: .abf
- Available for Windows and Mac OS
Discover how easy it is to use EZ Patch by watching the demo videos in the Videos section below.

How to connect ePatch in a typical patch-clamp setup
Technical specifications Voltage Clamp
- Open input (RMS) noise: 300 fA rms @ 625 Hz – 1.5 pA rms @ 10 kHz – 12 pA rms @ 100 kHz
- Current ranges: ±200 pA (Gain 2.25 GΩ), ±2 nA (Gain 225 MΩ), ±20 nA (Gain 22.5 MΩ), ±200 nA (Gain 2.25 MΩ)
- Parametric voltage protocols for pulse generator in the range of ±500 mV
- C fast compensation range: 0-11 pF
- C slow comepensation range: C in 0-250 pF – Tau in 0-2500 μs
- R series compensation range: 0-25 MΩ
- Auto electrodes voltage offset fine compensation
- Zap pulse
Technical specifications Current Clamp
- Input (RMS) noise: 11 μV rms @ 625 Hz – 22 μV rms @ 10 kHz – 350 μV rms @ 100 kHz
- Parametric current protocols for pulse generator in the range of ±2.5 nA (res. 0.2 pA) and ±100 nA (res. 10 pA)
- Voltage range: ±700 mV
- Pipette neutralization range: 0-31 pF
- Bridge Balance compensation range: 0-40 MΩ
- True-zero current mode
Other technical specifications
- Available bandwidth between 625 Hz to 100 kHz
- Max sampling rate: 200 ksps
- Data output format .abf
- USB powered
- Dovetail or rod bar mounting
- Available 0-5V programmable digital output
- Size & Weight: 42 x 18 x 78 mm, 200 g
- Quick Guide: Setup and Software installation
- Quick Guide: User Software Interface – basic commands
- Quick Guide: Record, display and save data
- Quick Guide: Protocol editor
- Quick Guide: Compensations
- Quick Guide: On-Line analyses
- Quick Guide: Programmable Digital Output
- Application Note: how to use ePatch for BLM experiments
NOTE: EDR Episodic is replaced by EZ Patch since 07-2019. If you bought your ePatch before this date contact info@elements-ic.com to get a firmware update.
- Rational design of a mutation to investigate the role of the brain protein TRIP8b in limiting the cAMP response of HCN channels in neurons, A. Porro et al
- The HCN domain couples voltage gating and cAMP response in hyperpolarization-activated cyclic nucleotide-gated channels, A. Porro et al
- Actin filaments modulate electrical activity of brain microtubule protein two-dimensional sheets, M. R. Cantero et al
- Investigating the effects of lamotrigine on HCN channels: a test case for a new miniaturized patch-clamp amplifier, A. Porro et al
- Helices D and E of HCN4 channel tune the CAMP responsiveness, A. Porro et al