eONE family

The world’s smallest current amplifier for nanopores and single-channel electrophysiology applications.

eONE is suitable for research and educational activities which use bilayer lipid membranes (BLM) or solid-state nanopores.

eONE is a complete, USB-powered, single-channel acquisition system: it incorporates the low noise amplifier, the digitizer and filters, and the voltage stimulus generator, all in a very small footprint: only 30x15x74mm.

A small, easy-to-use, USB plug’n play system for acquiring very-low-current signals!


How to connect eONE in a typical setup

Noise Comparison

eONE StdDev: 1.0212 pA

Amplifier 1 StdDev: 0.7222 pA

Amplifier 2 StdDev: 1.0781 pA

Test conditions: R load 500 MΩ, C load 25pF, 10 ksps, 5 kHz final bandwidth.

eONE versions

eONE is available in five different versions. They differ in the max signal bandwidth, voltage stimulus range and protocols, input current ranges.

Which eONE version has the characteristics you need?

Base Voltage Protocol High Speed eXtended Voltage  e1b (new!)
Current Ranges ±200pA; ±20nA ±200pA; ±20nA ±200pA; ±20nA ±200pA; ±20nA

±200pA; ±2nA

±20nA; ±200nA

Max Bandwidth 10 kHz 10 kHz 100 kHz 100 kHz 100 kHz
Resistance estimator V V V V V
Capacitane estimator V V V V V
Voltage range ±380mV ±380mV ±380mV ±1650mV ±2000mV
Voltage protocols Only constant voltage V V V V

Common features to all the eONE versions

Noise ~100 fA rms @ 1 kHz (gain 2.25GΩ)

~380 fA rms @ 10 kHz (gain 2.25 GΩ)

~3,2 pA rms @ 100 kHz (gain 2.25 GΩ)

Ground connector 2 mm banana plug
Max Sampling Rate 200 ksps PC interface USB 2.0 plug n’ play – mini B connector
Filters Digital Software interface Elements Data Reader, LabView® VI
ADC resolution 16 bit Data output format .dat – .abf
Offset compensation ± 128 mV Size&Weight 30x15x74mm-40g
Input Connector SMB Power Consumption 850 mW





  • Electroosmotic Trap Against the Electrophoretic Force Near a Protein Nanopore Reveals Peptide Dynamics During Capture and Translocation. Applied materials & interfaces, group of Dr. Tudor Luchian and others, 2016. https://pubs.acs.org/doi/10.1021/acsami.6b03697